Peroxisomal protein translocation
نویسندگان
چکیده
منابع مشابه
Pex17p of Saccharomyces cerevisiae Is a Novel Peroxin and Component of the Peroxisomal Protein Translocation Machinery
The Saccharomyces cerevisiae pex17-1 mutant was isolated from a screen to identify mutants defective in peroxisome biogenesis. pex17-1 and pex17 null mutants fail to import matrix proteins into peroxisomes via both PTS1- and PTS2-dependent pathways. The PEX17 gene (formerly PAS9; Albertini, M., P. Rehling, R. Erdmann, W. Girzalsky, J.A.K.W. Kiel, M. Veenhuis, and W.-H Kunau. 1997. Cell. 89:83-9...
متن کاملThe importomer--a peroxisomal membrane complex involved in protein translocation into the peroxisome matrix.
The import of proteins into the peroxisome matrix is an essential step in peroxisome biogenesis, which is critical for normal functioning of most eukaryotic cells. The translocation of proteins across the peroxisome membrane and the dynamic behavior of the import receptors during the import cycle is facilitated by several peroxisome-membrane-associated protein complexes, one of which is called ...
متن کاملPeroxisomal matrix protein receptor ubiquitination and recycling.
The peroxisomal targeting signal type1 (PTS1) receptor Pex5 is required for the peroxisomal targeting of most matrix proteins. Pex5 recognises target proteins in the cytosol and directs them to the peroxisomal membrane where cargo is released into the matrix, and the receptor shuttles back to the cytosol. Recently, it has become evident that the membrane-bound Pex5 can be modified by mono- and ...
متن کاملRecent advances in peroxisomal matrix protein import.
Peroxisomes are essential organelles responsible for many metabolic reactions, such as the oxidation of very long chain and branched fatty acids, D-amino acids and polyamines, as well as the production and turnover of hydrogen peroxide. They comprise a class of organelles called microbodies, including glycosomes, glyoxysomes and Woronin bodies. Dysfunction of human peroxisomes causes severe and...
متن کاملPeroxisomal Protein Import The Paradigm Shifts
oxisomal matrix proteins are imported into the organelle from their site of synthesis on free cytoplasmic ribo-somes. This observation led to the classical model of peroxisome proliferation in which existing peroxisomes Amherst, Massachusetts 01003 increase in size via the direct import of proteins from the cytoplasm, and divide by fission or budding (La-zarow and Fujiki, 1985). As such, the bi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2010
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2010.01.002